The Middle East and North Africa region is home to one of the largest cohorts of youth and the largest burden of displaced populations in the world. Improving the health and well-being of the adolescent demographic (10-19 years) in places like the West Bank and Gaza require targeted approaches that work in situations of acute, protracted, or cyclical conflict. The needs of adolescents are of special importance because many decisions and behaviours adopted during this relatively short period of time can have lifelong impacts on health and well-being. A functioning health information system is essential for decision-making to support better adolescent health outcomes. This project is implemented in collaboration with Birzeit University, located in the West Bank. It will inform current and future HIS planning and implementation for adolescent reproductive health in the West Bank and Gaza by generating evidence about its technical, social, and operational drivers, and recommendations to address gaps in data, indicators, and analysis. It will explore the factors that influence the design and operation of a health information system for adolescent health in contexts of acute and protracted conflict, and the resulting conditions of fragility. Government entities and communities will be engaged in a co-design and co-implementation approach to ensure future integration of the recommendations in the health information system. A cross-cutting focus on sound gender analysis and research ethics is integrated across the project, including how the questions and activities are framed and carried out, and how data is analyzed and used. Gender issues will be studied at the systems level, examining gender dimensions such as who decides on the indicators, who collects, analyzes, and uses the data, the level of women's involvement in decision-making and planning adolescent services, as well as the gender differences in workload and unpaid work related to a health information system for adolescent health. A strong capacity-strengthening strategy includes the training of graduate students, most of whom are women.