This project seeks to improve the quality and timeliness of evidence-based decision-making to improve child health outcomes in rural Ghana. This will be achieved by establishing a sustainable health information system that collects data on under-five children from their caregivers and health facilities and strengthening the capacity of various stakeholders to adequately use that data. In Ghana, as in many low and middle income countries, the majority of the  under five deaths are preventable and caused by infectious diseases. A well-functioning health system with robust health information system could deliver real-time data to assist in managing these illnesses. In an attempt to address such information gaps, the Ghana Health Service introduced the District Health Information and Management System software in 2012. However, this system is not operational in rural parts of Ghana. Health facilities in these hard to reach communities still rely on paper-based reporting system which is often erroneous, incomplete and not readily available for prompt decision-making.This project will utilize the multi-purpose function of a mobile phone-based health information system to empower caregivers to identify health problems of their children under five years of age. The system will link them up with a centralized system with an in-built algorithm to collect data on the children's symptoms and allow the caregivers to interact with health workers for further advice and follow-up. At the same time, this system will link with the Ghana Health service system to provide real-time data for decision making at both central and peripheral level. In addition to publications, this project will result in improved quality of data, access to and use of reliable health information from local to central levels, with an enhanced capacity of caregivers to identify childhood infectious diseases and to seek early intervention for better child health outcomes.This project represents one of nine selected as a cohort of implementation research projects spanning two regions (West Africa and the Middle East) and two thematic topics (adolescent sexual and reproductive health and health information systems). The project is closely aligned with the Government of Canada's new feminist international assistance policy, the strategic priorities detailed in the 2016-2030 World Health Organization (WHO) led Global Strategy for Women, Children and Adolescents, and the overarching 2030 global agenda for sustainable development.